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Lacosamide

拉科醯胺

Mechanism of action:

Lacosamide 是一種功能性胺基酸衍生物（functionalized amino acid）。Lacosamide 能促進電壓門控鈉離子通道（voltage-gated Na⁺ channels）的慢速不活化（slow inactivation），使過度興奮或病理性活化的神經元，長時間維持在不易再度放電的狀態。透過穩定神經元膜電位，lacosamide 能抑制異常高頻放電，同時保留正常神經傳導功能。

​Reference(s):

1. Sheets PL et al. (2008). Differential block of sensory neuronal voltage-gated sodium channels by lacosamide [(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine. J Pharmacol Exp Ther. 


2. Curia G et al. (2009). Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 


3. Perucca E et al. (2008). Lacosamide. Nat Rev Drug Discov.

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