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The Sound of Evolution
Latanoprost
拉坦前列素
Mechanism of action:
Latanoprost 是一種前列腺素 F₂α 類衍生物（prostaglandin F₂α analog）。Latanoprost 為前驅藥，經角膜吸收後，在眼內被酯酶水解為活性型 latanoprost acid。活性型 latanoprost acid 會結合於睫狀肌與鞏膜上的前列腺素 F 受體（prostaglandin F receptor），啟動下游訊號傳遞。透過誘導基質金屬蛋白酶（matrix metalloproteinase）表達，改變睫狀肌細胞外基質結構，使房水更容易經由葡萄膜-鞏膜途徑排出眼外，從而有效降低眼內壓。
Reference(s):
1. Hara T et al. (2001). Increased iris pigmentation after use of latanoprost in Japanese brown eyes. Nippon Ganka Gakkai Zasshi.
2. Patel SS et al. (1996). Latanoprost: a review of its pharmacological properties, clinical efficacy and tolerability in the management of primary open-angle glaucoma and ocular hypertension. Drugs Aging.
3. Alm A et al. (2014). Latanoprost in the treatment of glaucoma. Clin Ophthalmol.
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