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The Sound of Evolution
Lepirudin
來匹盧定
Mechanism of action:
Lepirudin 是一種直接凝血酶抑制劑（direct thrombin inhibitor），屬於重組水蛭素（recombinant hirudin）。Lepirudin 同時結合凝血酶（thrombin）的活性位點以及纖維蛋白原（fibrinogen）結合位點（exosite 1），形成高度穩定的複合體。隨後凝血酶無法將纖維蛋白原（fibrinogen）轉換為纖維蛋白（fibrin），降低凝血酶介導的凝血級聯反應與血栓形成。
Reference(s):
1. Smythe MA et al. (2005). A comparison of lepirudin and argatroban outcomes. Clin Appl Thromb Hemost.
2. Tardy B et al. (2006). Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudin. Blood.
3. Lubenow N et al. (2005). Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3. J Thromb Haemost.
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