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Levodopa

左旋多巴

Mechanism of action:

Levodopa 是一種多巴胺前驅物（dopamine precursor）。多巴胺本身無法有效通過血腦障壁，而 levodopa 可經由 大型中性胺基酸轉運蛋白（large neutral amino acid transporter）進入中樞神經系統。Levodopa 進入腦內後，由芳香族 L-胺基酸脫羧酶（aromatic L-amino acid decarboxylase）轉化為多巴胺（dopamine），補充因黑質-紋狀體路徑退化所缺乏的多巴胺。

​Reference(s):

1. Djamshidian A et al. (2016). Apomorphine and levodopa in Parkinson's disease: Two revolutionary drugs from the 1950's. Parkinsonism Relat Disord. 


2. Meiser J et al. (2013). Complexity of dopamine metabolism. Cell Commun Signal. 


3. Elroby SA et al. (2012). Toward the understanding of the metabolism of levodopa I. DFT investigation of the equilibrium geometries, acid-base properties and levodopa-water complexes. Int J Mol Sci.

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