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Levofloxacin

左氧氟沙星

Mechanism of action:

Levofloxacin 是一種氟喹諾酮類抗生素（fluoroquinolone antibiotic），屬於氧氟沙星（Ofloxacin）的 L-對映異構物（L- enantiomer）。Levofloxacin 會作用於 DNA 拓撲異構酶（topoisomerase）。拓撲異構酶 II（topoisomerase II）負責解除 DNA 複製過程中產生的超螺旋結構，levofloxacin 抑制該酵素後，DNA 無法正常展開與複製。拓撲異構酶 IV（topoisomerase IV）負責在細胞分裂時分離已複製完成的 DNA，其活性如果受 levofloxacin 抑制，會導致細菌細胞分裂失敗。

​Reference(s):

1. Fish DN et al. (1997). The clinical pharmacokinetics of levofloxacin. Clin Pharmacokinet. 


2. Giri P et al. (2017). Evaluation of In Vitro Cytochrome P450 Inhibition and In Vitro Fate of Structurally Diverse N-Oxide Metabolites: Case Studies with Clozapine, Levofloxacin, Roflumilast, Voriconazole and Zopiclone. Eur J Drug Metab Pharmacokinet. 


3. Sato T et al. (2017). Potential Drug Interactions Mediated by Renal Organic Anion Transporter OATP4C1. J Pharmacol Exp Ther.

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