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Lidocaine

利多卡因

Mechanism of action:

Lidocaine 是一種醯胺類（amide）衍生物。Lidocaine 能阻斷電壓門控鈉離子通道（voltage-gated Na⁺ channel），且偏好結合於開啟狀態與不活化態的鈉離子通道，阻止鈉離子內流，抑制動作電位的去極化（depolarization），使神經或心肌細胞無法產生或傳導動作電位。

​Reference(s):

1. Khaliq W et al. (2007). Topical lidocaine for the treatment of postherpetic neuralgia. Cochrane Database Syst Rev. 


2. Thomson PD et al. (1973). Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans. Ann Intern Med. 


3. Geha PY et al. (2007). Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy. Pain.

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