top of page
< Back

Linagliptin

利格列汀

Mechanism of action:

Linagliptin 是一種二肽基肽酶-4 抑制劑（dipeptidyl peptidase-4 inhibitor）。二肽基肽酶-4（DPP-4）是一種負責分解腸泌素的酵素，腸泌素比如胰高血糖素樣肽-1（glucagon-like peptide-1）和葡萄糖依賴性促胰島素多肽（glucose-dependent insulinotropic polypeptide）等。當 linagliptin 抑制二肽基肽酶-4 後，使腸泌素不易被分解，在血中濃度與作用時間延長，進而增加腸泌素介導的胰島素分泌訊號，並降低升糖素分泌訊號（glucagon）。

​Reference(s):

1. Forst T et al. (2012). Linagliptin, a dipeptidyl peptidase-4 inhibitor with a unique pharmacological profile, and efficacy in a broad range of patients with type 2 diabetes. Expert Opin Pharmacother. 


2. Blech S et al. (2010). The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans. Drug Metab Dispos.

bottom of page