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The Sound of Evolution
Lorazepam
勞拉西泮
Mechanism of action:
Lorazepam 是一種苯二氮平類（benzodiazepine）衍生物。Lorazepam 會結合於 GABA_A 受體的苯二氮平結合位點（benzodiazepine-binding site），增加 GABA_A 受體的抑制作用，使氯離子通道開啟頻率上升，導致氯離子流入神經元，引起膜超極化（hyperpolarization），而產生抗焦慮、鎮靜與催眠、抗痙攣等。
Reference(s):
1. Kemper N et al. (1980). Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed. Dtsch Med Wochenschr.
2. Lader M et al. (1984). Short-term versus long-term benzodiazepine therapy. Curr Med Res Opin.
3. Maltais F et al. (1996). A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy. Chest.
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