top of page
The Sound of Evolution
Lovastatin
洛伐他汀
Mechanism of action:
Lovastatin 是一種 HMG-CoA 還原酶抑制劑（HMG-CoA reductase inhibitor）。Lovastatin 會與 HMG-CoA 還原酶結合，抑制其將 HMG-CoA 轉化為甲羥戊酸（mevalonate），降低肝臟內膽固醇生成，使肝細胞內膽固醇濃度下降，之後導致上調肝細胞的 LDL 受體表達，增強血液的低密度脂蛋白膽固醇（LDL-C）的攝取與分解。最終血漿中 LDL-C、總膽固醇、極低密度脂蛋白（VLDL）以及三酸甘油脂可下降，同時高密度脂蛋白膽固醇（HDL-C）可能輕微上升。
Reference(s):
1. Boruta T et al. (2017). Production of lovastatin and itaconic acid by Aspergillus terreus: a comparative perspective. World J Microbiol Biotechnol.
2. Alberts AW et al. (1980). Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proc Natl Acad Sci U S A.
3. Endo A et al. (2004). The origin of the statins. Atheroscler Suppl.
bottom of page