The Sound of Evolution
Meclofenamate
甲氧胺苯酸鈉
Mechanism of action:
Meclofenamate 是一種鄰胺基苯甲酸類（anthranilic acid）衍生物。Meclofenamate 會抑制環氧化酶（cyclooxygenase），包含 COX-1 與 COX-2，阻斷花生四烯酸（arachidonic acid）轉化為前列腺素（prostaglandin）與血栓素（thromboxane），降低前列腺素/血栓素介導的發炎訊號與疼痛敏感化。
Reference(s):
1. Perez-Vizcaino F et al. (2002). Postnatal maturation in nitric oxide-induced pulmonary artery relaxation involving cyclooxygenase-1 activity. Am J Physiol Lung Cell Mol Physiol.
2. Shiels IA et al. (2000). Lyprinol: anti-inflammatory and uterine-relaxant activities in rats, with special reference to a model for dysmenorrhoea. Allerg Immunol (Paris).
3. Wilson JE et al. (2004). Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res.