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Mefloquine

美爾奎寧

Mechanism of action:

Mefloquine 是一種喹啉甲醇類（quinoline methanol）衍生物。Mefloquine 會累積於瘧原蟲的食物液泡（food vacuole）內。瘧原蟲在紅血球內會分解血紅素作為胺基酸來源，同時產生具毒性的游離血基質（heme）。正常情況下，瘧原蟲會將血基質聚合為無毒的瘧色素（hemozoin）。Mefloquine 能抑制游離血基質轉變為瘧色素，使寄生蟲體內累積血基質，導致死亡。

​Reference(s):

1. Nevin RL et al. (2017). A serious nightmare: psychiatric and neurologic adverse reactions to mefloquine are serious adverse reactions. Pharmacol Res Perspect. 


2. Palmer KJ et al. (1993). Mefloquine: a review of its antimalarial activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 


3. Tickell-Painter M et al. (2017). Mefloquine for preventing malaria during travel to endemic areas. Cochrane Database Syst Rev.

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