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Mepivacaine

甲哌卡因

Mechanism of action:

Mepivacaine 是一種醯胺類（amide）衍生物。Mepivacaine 可由神經細胞膜進入細胞內，結合於鈉離子通道（sodium channel）的內側結合位點，抑制鈉離子在去極化時流入神經元。神經膜無法達到去極化閾值，動作電位就無法產生與向前傳導，因此痛覺、觸覺與溫度覺訊號無法傳至中樞神經系統。

​Reference(s):

Leffler A et al. (2010). Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. Eur J Pharmacol.

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