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Meropenem

美羅培南

Mechanism of action:

Meropenem 是一種 β-內醯胺類抗生素（β-lactam antibiotic），屬於碳青黴烯類（carbapenem）。Meropenem 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌破裂死亡。

​Reference(s):

1. Kanazawa K et al. (1997). Structure-activity relationships of carbapenem compounds to anti-Haemophilus influenzae activity and affinity for penicillin-binding proteins. Effect of 1 beta-methyl group and C-2 side chain. J Antibiot (Tokyo). 


2. Ubukata K et al. (2001). Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother.

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