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Metaxalone

美他沙酮
Mechanism of action:
Metaxalone 是一種中樞性骨骼肌鬆弛劑(centrally acting skeletal muscle relaxant),屬於噁唑烷酮類(oxazolidinone)衍生物。Metaxalone 的確切分子機制尚未完全釐清,但被認為可抑制腦幹與脊髓層級的多突觸反射活動,降低促進肌肉張力的神經訊號傳遞。Metaxalone 不直接影響骨骼肌的收縮機制。
Reference(s):
1. See S et al. (2008). Choosing a skeletal muscle relaxant. Am Fam Physician.
2. Elenbaas JK et al. (1980). Centrally acting oral skeletal muscle relaxants. Am J Hosp Pharm.
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