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The Sound of Evolution
Methicillin
甲氧西林
Mechanism of action:
Methicillin 是一種 β-內醯胺類抗生素（β-lactam antibiotic），屬於半合成青黴素（semisynthetic penicillin）。Methicillin 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌破裂死亡。
Reference(s):
1. Gardete S et al. (2006). A link in transcription between the native pbpB and the acquired mecA gene in a strain of Staphylococcus aureus. Microbiology.
2. Williamson R et al. (1980). In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother.
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