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Methyldopa

甲基多巴

Mechanism of action:

Methyldopa 是一種 α₂-腎上腺素受體促效劑（α₂-adrenergic agonist）。Methyldopa 為前驅藥，進入中樞神經系統後，經由芳香族 L-胺基酸脫羧酶（aromatic L-amino acid decarboxylase）與多巴胺 β-羥化酶（dopamine β-hydroxylase）轉化為具有活性的 α-methylnorepinephrine。α-methylnorepinephrine 會刺激腦幹（特別是延腦血管運動中樞）中的 α₂-腎上腺素受體，抑制交感神經的中樞輸出，使週邊血管阻力下降、心跳速率與心輸出量降低等。

​Reference(s):

1. Mah GT et al. (2009). Methyldopa for primary hypertension. Cochrane Database Syst Rev. 


2. Sica DA et al. (2007). Centrally acting antihypertensive agents: an update. J Clin Hypertens (Greenwich). 


3. van Zwieten PA et al. (1980). Pharmacology of centrally acting hypotensive drugs. Br J Clin Pharmacol.

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