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Methylphenidate

派醋甲酯

Mechanism of action:

Methylphenidate 是一種哌啶類（piperidine）衍生物。Methylphenidate 主要抑制多巴胺轉運蛋白（dopamine transporter）與正腎上腺素轉運蛋白（norepinephrine transporter）。使多巴胺（dopamine）與正腎上腺素（norepinephrine）無法被神經末梢回收，導致其在突觸間隙中的濃度上升，強化對神經元的刺激。

​Reference(s):

1. Keating GM et al. (2001). Methylphenidate (OROS formulation). CNS Drugs. 


2. Markowitz JS et al. (2006). A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study. J Child Adolesc Psychopharmacol. 


3. Fone KC et al. (2005). Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder. Curr Opin Pharmacol.

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