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The Sound of Evolution
Miconazole
咪康唑
Mechanism of action:
Miconazole 是一種咪唑類（imidazole）衍生物。Miconazole 能抑制黴菌的羊毛甾醇-14α-脫甲基酶（lanosterol 14α-demethylase，CYP51），該酵素負責將羊毛固醇（lanosterol）轉化為麥角固醇（ergosterol）。當此步驟被阻斷，黴菌的細胞膜結構會變得不完整，且羊毛固醇因為無法轉化而不斷堆積，引起毒性，最終讓真菌生長受抑或發生細胞損傷。
Reference(s):
1. Taudorf EH et al. (2019). Cutaneous candidiasis - an evidence-based review of topical and systemic treatments to inform clinical practice. J Eur Acad Dermatol Venereol.
2. Tanenbaum L et al. (1984). 1% sulconazole cream v 2% miconazole cream in the treatment of tinea versicolor. A double-blind, multicenter study. Arch Dermatol.
3. Pierard GE et al. (2012). Miconazole, a pharmacological barrier to skin fungal infections. Expert Opin Pharmacother.
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