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The Sound of Evolution
Midazolam
咪達唑侖
Mechanism of action:
Midazolam 是一種 1,4-苯二氮平類（1,4-benzodiazepine）衍生物。Midazolam 結合於 GABA_A 受體的苯二氮平結合位點，增進 GABA 對於該受體的作用，提高氯離子通道開啟頻率，使大量氯離子流入神經元，造成超極化（hyperpolarization），讓神經元較難被激發。
Reference(s):
1. Skerritt JH et al. (1983). Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur J Pharmacol.
2. Isojarvi JI et al. (1998). Benzodiazepines in the treatment of epilepsy in people with intellectual disability. J Intellect Disabil Res.
3. Garratt JC et al. (1988). Can benzodiazepines be classified by characterising their anticonvulsant tolerance-inducing potential? Eur J Pharmacol.
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