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Milnacipran

米那普侖

Mechanism of action:

Milnacipran 是一種正腎上腺素-血清素再回收抑制劑（serotonin-norepinephrine reuptake inhibitor）。Milnacipran 能抑制正腎上腺素轉運蛋白（norepinephrine transporter）和血清素轉運蛋白（serotonin transporter），使正腎上腺素和血清素無法回收，導致神經元突觸間隙的正腎上腺素和血清素量升高，延長神經傳導的作用時間。Milnacipran 對正腎上腺素轉運蛋白的抑制強度大於血清素轉運蛋白。

​Reference(s):

1. Leo RJ et al. (2006). Clinical potential of milnacipran, a serotonin and norepinephrine reuptake inhibitor, in pain. Curr Opin Investig Drugs. 


2. Sato S et al. (2006). Efficacy of milnacipran on cognitive dysfunction with post-stroke depression: preliminary open-label study. Psychiatry Clin Neurosci.

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