top of page
The Sound of Evolution
Mirtazapine
米氮平
Mechanism of action:
Mirtazapine 是一種正腎上腺素與特殊血清素受體抗憂鬱劑（noradrenergic and specific serotonergic antidepressant）。Mirtazapine 會阻斷中樞 α₂ 自體受體（autoreceptor）與異源受體（heteroreceptor）。α₂ 自體受體負責抑制正腎上腺素（norepinephrine）釋放；α₂ 異源受體負責抑制血清素（5-HT）釋放。Mirtazapine 阻斷這些 α₂ 受體能增加正腎上腺素與血清素的釋放。此外，mirtazapine 也會阻斷 5-HT₂ 和 5-HT₃ 受體，使血清素作用偏向 5-HT₁A 受體。
Reference(s):
1. Gillman PK et al. (2006). A systematic review of the serotonergic effects of mirtazapine in humans: implications for its dual action status. Hum Psychopharmacol.
2. Burrows GD et al. (1997). Mirtazapine: clinical advantages in the treatment of depression. J Clin Psychopharmacol.
3. Velazquez C et al. (2001). Relative safety of mirtazapine overdose. Vet Hum Toxicol.
bottom of page