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Moclobemide

嗎氯貝胺

Mechanism of action:

Moclobemide 是一種可逆性單胺氧化酶 A 抑制劑（reversible monoamine oxidase A inhibitor）。Moclobemide 能可逆性且選擇性地抑制單胺氧化酶 A（monoamine oxidase A），使血清素（5-HT）和正腎上腺素（NE）分解減少，提升突觸間隙的血清素和正腎上腺素濃度，延長神經傳遞物質的作用時間。

​Reference(s):

1. Bonnet U et al. (2003). Moclobemide: therapeutic use and clinical studies. CNS Drug Rev. 


2. Gram LF et al. (1995). Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: a panel study. Clin Pharmacol Ther.

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