The Sound of Evolution
Nabilone
那密濃
Mechanism of action:
Nabilone 是一種合成大麻素（synthetic cannabinoid）衍生物。Nabilone 為大麻素受體1 和2（cannabinoid receptor 1 ands 2）的促效劑。大麻素受體1 主要分佈於大腦與脊髓，nabilone 能抑制興奮性神經傳遞物質（如麩胺酸，glutamate、P 物質，substance P）的釋放。大麻素受體2 主要分佈在免疫細胞，nabilone 對於大麻素受體2 作用會降低發炎性細胞激素的產生。
Reference(s):
1. Cunningham D et al. (1988). A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues. Eur J Cancer Clin Oncol.
2. Niiranen A et al. (1987). Antiemetic efficacy of nabilone and dexamethasone: a randomized study of patients with lung cancer receiving chemotherapy. Am J Clin Oncol.
3. Herman TS et al. (1979). Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. N Engl J Med.