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Nadroparin

那屈肝素

Mechanism of action:

Nadroparin 是一種低分子量肝素（low molecular weight heparin）。Nadroparin 會與抗凝血酶 III（antithrombin III）結合，增強對凝血因子 Xa（factor Xa）的抑制作用，使凝血因子 Xa 無法促進凝血酶生成（降低凝血酶原轉化為凝血酶的效率），阻斷了之後纖維蛋白（fibrin）的形成，防止血栓生成。

​Reference(s):

1. Collignon F et al. (1995). Comparison of the pharmacokinetic profiles of three low molecular mass heparins--dalteparin, enoxaparin and nadroparin--administered subcutaneously in healthy volunteers (doses for prevention of thromboembolism). Thromb Haemost. 


2. Frydman A et al. (1996). Low-molecular-weight heparins: an overview of their pharmacodynamics, pharmacokinetics and metabolism in humans. Haemostasis. 


3. Lai KN et al. (1996). Use of low-dose low molecular weight heparin in hemodialysis. Am J Kidney Dis.

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