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Nafarelin

那法瑞林

Mechanism of action:

Nafarelin 是一種促性腺激素釋放激素（gonadotropin-releasing hormone）的類似物。在初期，Nafarelin 會持續刺激腦下垂體前葉的促性腺激素釋放激素受體（GnRH receptor），使黃體成長激素（LH）與濾泡刺激素（FSH）短暫上升，造成性荷爾蒙（睪酮或雌激素）暫時增加。隨著持續提供，促性腺激素釋放激素受體因長期刺激而發生去敏感化與數量下降，腦下垂體對促性腺激素釋放激素反應明顯減弱，使黃體成長激素和濾泡刺激素開始減少，進而降低性荷爾蒙產量。

​Reference(s):

1. Hugues JN et al. (1998). Revisiting gonadotrophin-releasing hormone agonist protocols and management of poor ovarian responses to gonadotrophins. Hum Reprod Update. 


2. Garner C et al. (1994). Uses of GnRH agonists. J Obstet Gynecol Neonatal Nurs. 


3. Henzl MR et al. (1992). Gonadotropin-releasing hormone analogs: update on new findings. Am J Obstet Gynecol.

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