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Nateglinide

那格列奈

Mechanism of action:

Nateglinide 是一種苯甲酸類（benzoic acid）衍生物。Nateglinide 能結合並抑制胰島 β 細胞膜上的磺醯脲受體 1（SUR1），此受體為 ATP-敏感鉀離子通道蛋白（ATP-sensitive potassium channel）的調節亞基。被 nateglinide 抑制後，鉀離子外流減少，細胞膜發生去極化（depolarization）。去極化會造成鈣離子通道（calcium channel）開啟，鈣離子內流增加，促使胰島素釋放。

​Reference(s):

1. Hu S et al. (2000). Pancreatic beta-cell K(ATP) channel activity and membrane-binding studies with nateglinide: A comparison with sulfonylureas and repaglinide. J Pharmacol Exp Ther. 


2. Sunaga Y et al. (2001). The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide. Eur J Pharmacol.

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