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Neomycin

新黴素
Mechanism of action:
Neomycin 是一種胺基醣苷類抗生素(aminoglycoside antibiotic)。Neomycin 能不可逆地結合於 30S 核糖體亞基,影響 mRNA 的正確解讀,導致錯誤胺基酸被摻入蛋白質,生成異常或無功能蛋白質。
Reference(s):
1. Lechevalier HA et al. (1975). The 25 years of neomycin. CRC Crit Rev Microbiol.
2. Macdonald RH et al. (1983). Neomycin: a review with particular reference to dermatological usage. Clin Exp Dermatol.
3. Dlugosz M et al. (2009). Aminoglycoside association pathways with the 30S ribosomal subunit. J Phys Chem B.
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