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Neostigmine

新斯狄明

Mechanism of action:

Neostigmine 是一種膽鹼酯酶抑制劑（acetylcholinesterase inhibitor），屬於季銨胺基甲酸酯（quaternary ammonium carbamate）衍生物。Neostigmine 會可逆性地對乙醯膽鹼酯酶（acetylcholinesterase）進行氨基甲醯化（carbamylation），使酵素活性被抑制，無法分解乙醯膽鹼（acetylcholine），導致神經元突觸間隙乙醯膽鹼濃度增加，增強神經肌肉接點的訊號傳遞。

​Reference(s):

1. Trevisani GT et al. (2000). Neostigmine: safe and effective treatment for acute colonic pseudo-obstruction. Dis Colon Rectum. 


2. Naves LA et al. (2001). Repetitive nerve stimulation decreases the acetylcholine content of quanta at the frog neuromuscular junction. J Physiol. 


3. Takeuchi K et al. (2000). Stimulation by nizatidine, a histamine H(2)-receptor antagonist, of duodenal HCO(3)(-) secretion in rats: relation to anti-cholinesterase activity. World J Gastroenterol.

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