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Nisoldipine

尼索地平

Mechanism of action:

Nisoldipine 是一種鈣離子通道阻斷劑（calcium channel blocker），屬於二氫吡啶類（dihydropyridine）衍生物。Nisoldipine 主要作用於血管平滑肌細胞，阻斷 L 型鈣離子通道（L-type calcium channel） ，使鈣離子流入細胞質的量下降，導致血管平滑肌放鬆，血壓降低。

​Reference(s):

1. Mielcarek J et al. (2005). The effect of beta-carotene on the photostability of nisoldipine. Methods Find Exp Clin Pharmacol. 


2. Missan S et al. (2003). Block of cardiac delayed-rectifier and inward-rectifier K⁺ currents by nisoldipine. Br J Pharmacol. 


3. Hamilton SF et al. (1999). Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure. Heart Dis.

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