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Nitrofurantoin

呋喃妥因

Mechanism of action:

Nitrofurantoin 是一種硝基呋喃類（nitrofuran）衍生物。Nitrofurantoin 進入細菌後，會被細菌的硝基還原酶（nitroreductase）還原，產生高活性的反應性中間物。這些活性中間物會同時攻擊細菌的 DNA、RNA、蛋白質、細胞膜等，造成細菌多層次損傷。

​Reference(s):

1. Mannisto PT et al. (1982). Nitrofurantoin is highly bound to plasma protein. J Antimicrob Chemother. 


2. McOsker CC et al. (1994). Nitrofurantoin: mechanism of action and implications for resistance development in common uropathogens. J Antimicrob Chemother.

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