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Nitroprusside

硝普鈉

Mechanism of action:

Nitroprusside 是一種亞硝基鐵氰化物複合體（nitroferricyanide complex）。Nitroprusside 進入血液後，與血紅素或血管平滑肌中的還原物質反應，迅速釋放一氧化氮，不依賴特定代謝酵素。一氧化氮擴散於細胞質後，活化鳥苷酸環化酶（guanylate cyclase），增加 cGMP 濃度，使細胞質的鈣離子濃度下降，導致血管平滑肌鬆弛。

​Reference(s):

1. Fortin Y et al. (2006). Role of cyclic GMP and calcineurin in homologous and heterologous desensitization of natriuretic peptide receptor-A. Can J Physiol Pharmacol. 


2. Madhani M et al. (2006). Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo. Br J Pharmacol. 


3. Steinmetz M et al. (2004). Diverging vasorelaxing effects of C-type natriuretic peptide in renal resistance arteries and aortas of GC-A-deficient mice. Regul Pept.

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