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Nitrous oxide

一氧化二氮
Mechanism of action:
Nitrous oxide 的作用並非單一受體,而是透過多重中樞神經調控機制。其中,nitrous oxide 能抑制 NMDA 受體,減弱 glutamatergic 興奮性神經傳導。Nitrous oxide 也會活化 μ-阿片受體(μ-opioid receptor),增加內啡肽(endorphin)與腦內啡(enkephalin)的釋放。
Reference(s):
Orestes P et al. (2011). Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol.
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