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Norelgestromin

諾孕曲明

Mechanism of action:

Norelgestromin 是一種合成黃體素（synthetic progestin），為 19-去甲睪酮（19-nortestosterone）衍生物。Norelgestromin 透過負回饋作用抑制下視丘-腦下垂體-性腺軸（hypothalamic-pituitary-gonadal axis），降低黃體成長激素（LH）峰值的產生，使卵泡無法正常破裂，從而抑制或延遲排卵。Norelgestromin 也會使子宮頸黏液變得濃稠，阻礙精子通過子宮頸進入子宮腔，降低受精可能性。此外，norelgestromin 能使子宮內膜維持在較薄、非增生狀態，即使受精發生，也不利於胚胎著床。

​Reference(s):

1. Goa KL et al. (2003). Transdermal ethinylestradiol/norelgestromin: a review of its use in hormonal contraception. Treat Endocrinol. 


2. Henzl MR et al. (2001). Norgestimate. From the laboratory to three clinical indications. J Reprod Med. 


3. Abrams LS et al. (2001). Pharmacokinetics of norelgestromin and ethinyl estradiol from two consecutive contraceptive patches. J Clin Pharmacol.

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