top of page
< Back

Nystatin

耐絲菌素

Mechanism of action:

Nystatin 是一種多烯類抗真菌劑（polyene antifungal agent），能優先結合真菌細胞膜上的麥角固醇（ergosterol），形成跨膜孔洞，導致滲透壓失衡、細胞內容物流失與細胞死亡。

​Reference(s):

1. Akaike N et al. (1994). Nystatin perforated patch recording and its applications to analyses of intracellular mechanisms. Jpn J Physiol. 


2. Dos Santos AG et al. (2017). The molecular mechanism of Nystatin action is dependent on the membrane biophysical properties and lipid composition. Phys Chem Chem Phys. 


3. Karlgren M et al. (2012). Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. J Med Chem.

bottom of page