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Olsalazine

奧沙拉秦

Mechanism of action:

Olsalazine 是一種 5-胺基水楊酸（5-aminosalicylic acid）的前驅藥，在結腸內轉化為 5-胺基水楊酸後進行藥理作用。5-胺基水楊酸能抑制環氧合酶（cyclooxygenase）和脂氧合酶（lipoxygenase），減少前列腺素（prostaglandin）與白三烯（leukotriene）的生成，降低腸道發炎反應。

​Reference(s):

1. Wadworth AN et al. (1991). Olsalazine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease. Drugs. 


2. Campbell DE et al. (1988). Pharmacology of olsalazine. Scand J Gastroenterol Suppl. 


3. Horn H et al. (1991). Modulation of arachidonic acid metabolism by olsalazine and other aminosalicylates in leukocytes. Scand J Gastroenterol.

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