The Sound of Evolution
Omega-3-acid ethyl esters
Omega-3 脂肪酸乙酯
Mechanism of action:
Omega-3-acid ethyl esters 是指 ω-3 多元不飽和脂肪酸乙酯混合物，主要成分為二十碳五烯酸（EPA，eicosapentaenoic acid）與二十二碳六烯酸（DHA，docosahexaenoic acid）的乙酯型態。EPA 與 DHA 會抑制肝臟脂肪酸合成，降低二酸甘油酯醯基轉移酶（diglyceride acyltransferase）活性，使肝臟合成三酸甘油脂（triglyceride）的能力下降，使極低密度脂蛋白（very low-density lipoprotein，VLDL）生成下降；也會活化與脂肪酸 β-氧化（β-oxidation）相關的核內受體（如 PPAR-α），增加肝臟與週邊組織對脂肪酸的利用。
Reference(s):
1. Braeckman RA et al. (2014). Pharmacokinetics of Eicosapentaenoic Acid in Plasma and Red Blood Cells After Multiple Oral Dosing With Icosapent Ethyl in Healthy Subjects. Clin Pharmacol Drug Dev.
2. Koski R et al. (2008). Omega-3-acid Ethyl Esters (Lovaza) For Severe Hypertriglyceridemia. Pharmacy and Therapeutics.
3. Davidson MH et al. (2013). Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. Curr Opin Lipidol.