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Oxiconazole

奧昔康唑

Mechanism of action:

Oxiconazole 是一種咪唑類（imidazole）衍生物。Oxiconazole 能抑制黴菌的羊毛甾醇-14α-脫甲基酶（lanosterol 14α-demethylase，CYP51），該酵素負責將羊毛固醇（lanosterol）轉化為麥角固醇（ergosterol）。當此步驟被阻斷，黴菌的細胞膜結構會變得不完整，且羊毛固醇因為無法轉化而不斷堆積，引起毒性，最終讓真菌生長受抑或發生細胞損傷。

​Reference(s):

1. Matsui H et al. (2008). Imidazole antifungals, but not triazole antifungals, increase membrane Zn²⁺ permeability in rat thymocytes: Possible contribution to their cytotoxicity. Toxicology. 


2. Fromtling RA et al. (1988). Overview of medically important antifungal azole derivatives. Clin Microbiol Rev.

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