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The Sound of Evolution
Oxybutynin
奧昔布寧
Mechanism of action:
Oxybutynin 是一種毒蕈鹼型乙醯膽鹼受體抑制劑（muscarinic acetylcholine receptor inhibitor），主要拮抗 M₃ 受體，M₁、M₂ 為次要。正常情況下，M₃ 受體若被活化，會藉由 Gq 蛋白使 IP₃/Ca²⁺ 上升，促進膀胱收縮。Oxybutynin 抑制 M₃ 受體後，能讓逼尿肌放鬆。
Reference(s):
1. Douchamps J et al. (1988). The pharmacokinetics of oxybutynin in man. Eur J Clin Pharmacol.
2. Kennelly MJ et al. (2010). A comparative review of oxybutynin chloride formulations: pharmacokinetics and therapeutic efficacy in overactive bladder. Rev Urol.
3. Yarker YE et al. (1995). Oxybutynin. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability. Drugs Aging.
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