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The Sound of Evolution
Pancuronium
泮庫溴銨
Mechanism of action:
Pancuronium 是一種非去極化型肌肉鬆弛劑（non-depolarizing neuromuscular blocker），屬於類固醇季銨化合物（steroidal quaternary ammonium compound）。Pancuronium 會與乙醯膽鹼（acetylcholine）競爭性結合於運動終板（motor end-plate）上的菸鹼型乙醯膽鹼受體（nicotinic acetylcholine receptor），使鈉離子無法內流，運動終板無法去極化（depolarization），導致骨骼肌無法收縮，呈現鬆弛狀態。
Reference(s):
1. Dilger JP et al. (2007). Roles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonists. Anesthesiology.
2. Jonsson Fagerlund M et al. (2009). Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology.
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