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Paroxetine

帕羅西汀

Mechanism of action:

Paroxetine 是一種選擇性血清素再回收抑制劑（selective serotonin reuptake inhibitor），屬於苯氧基苯丙胺類（phenoxyphenylpropylamine）衍生物。Paroxetine 會高親和力結合血清素轉運蛋白（serotonin transporter），阻止突觸前神經元將血清素（5-HT）回收，使突觸間隙中的血清素濃度上升，增強突觸後神經元的血清素受體活化。

​Reference(s):

1. Baldwin DS et al. (2005). Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology. J Psychopharmacol. 


2. Baldwin D et al. (1999). Paroxetine in social phobia/social anxiety disorder. Randomised, double-blind, placebo-controlled study. Paroxetine Study Group. Br J Psychiatry.

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