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Pegaspargase

培門冬酶

Mechanism of action:

Pegaspargase 是一種聚乙二醇化門冬醯胺酶（PEGylated L-asparaginase）。Pegaspargase 能將 L-天門冬醯胺（L-asparagine）分解為 L-天門冬胺酸（L-aspartic acid）+ 氨，使血漿中的 L-天門冬醯胺濃度大幅下降。白血病淋巴母細胞通常缺乏天門冬醯胺合成酶（asparagine synthetase），高度依賴外源性的天門冬醯胺，若血漿中缺乏 L-天門冬醯胺，會使白血病淋巴母細胞無法合成蛋白質

​Reference(s):

1. Graham ML et al. (2003). Pegaspargase: a review of clinical studies. Adv Drug Deliv Rev. 


2. Zeidan A et al. (2009). Pegasparaginase: where do we stand? Expert Opin Biol Ther. 


3. Heo YA et al. (2019). Pegaspargase: A Review in Acute Lymphoblastic Leukaemia. Drugs.

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