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The Sound of Evolution
Phenelzine
苯乙肼
Mechanism of action:
Phenelzine 是一種不可逆型單胺氧化酶抑制劑（irreversible monoamine oxidase inhibitor）。單胺氧化酶（monoamine oxidase，MAO）可分為 MAO-A 和 MAO-B，MAO-A 主要分解血清素（5-HT）、正腎上腺素（norepinephrine）與多巴胺（dopamine）；MAO-B 則主要分解多巴胺。Phenelzine 與單胺氧化酶共價結合，使酵素失去活性，減少神經傳導物質在突觸前的分解，使其在中樞神經系統中的濃度上升，調節與情緒相關的中樞神經傳導功能。
Reference(s):
1. Nolen WA et al. (2003). [Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression]. Ned Tijdschr Geneeskd.
2. Sowa BN et al. (2004). Monoamine oxidase inhibitors, their structural analogues, and neuroprotection. Indian J Exp Biol.
3. Todd KG et al. (2008). Neurochemical effects of the monoamine oxidase inhibitor phenelzine on brain GABA and alanine: A comparison with vigabatrin. J Pharm Pharm Sci.
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