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Phentolamine

酚妥拉明

Mechanism of action:

Phentolamine 是一種可逆型、非選擇性 α-腎上腺素受體阻斷劑（reversible non-selective α-adrenergic blocker）。Phentolamine 阻斷血管平滑肌的 α₁ 受體，使週邊血管擴張，降低血壓；對於神經元的 α₂ 受體，則能促進正腎上腺素（norepinephrine）釋放，引起反射性心搏加快（reflex tachycardia）。

​Reference(s):

1. Gould L et al. (1976). Phentolamine. Am Heart J. 


2. Raja SN et al. (1991). Systemic alpha-adrenergic blockade with phentolamine: a diagnostic test for sympathetically maintained pain. Anesthesiology.

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