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Physostigmine

毒扁豆鹼

Mechanism of action:

Physostigmine 是一種膽鹼酯酶抑制劑（cholinesterase inhibitor），屬於胺基甲酸酯類（carbamate）衍生物。Physostigmine 能和乙醯膽鹼酯酶（acetylcholinesterase）可逆性結合，暫時使酵素失去活性，減少乙醯膽鹼（acetylcholine）的水解，提升乙醯膽鹼在突觸間隙的濃度，這能增強各種類型的乙醯膽鹼受體（acetylcholine receptor）的作用。

​Reference(s):

1. Nguyen PV et al. (1999). Maturation of neuromuscular transmission during early development in zebrafish. J Neurophysiol. 


2. Tuovinen K et al. (1999). Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication. Toxicology. 


3. Blasina MF et al. (2000). Evidence for a noncholinergic function of acetylcholinesterase during development of chicken retina as shown by fasciculin. Cell Tissue Res.

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