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Pirenzepine

哌侖西平

Mechanism of action:

Pirenzepine 是一種選擇性毒蕈鹼型乙醯膽鹼受體拮抗劑（selective muscarinic acetylcholine receptor antagonist）。Pirenzepine 主要拮抗胃壁內神經叢（enteric nervous system）、中樞與週邊膽鹼能神經上的 M₁ 毒蕈鹼型受體。阻斷 M₁ 受體後，會抑制迷走神經對胃酸分泌的促進作用，降低胃酸分泌。

​Reference(s):

1. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res. 


2. Pedretti RF et al. (2003). Autonomic modulation during acute myocardial ischemia by low-dose pirenzepine in conscious dogs with a healed myocardial infarction: a comparison with beta-adrenergic blockade. J Cardiovasc Pharmacol.

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