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Piroxicam

吡羅昔康

Mechanism of action:

Piroxicam 是一種昔康類（oxicam）衍生物。Piroxicam 能抑制環氧化酶（cyclooxygenase），包含 COX-1 與 COX-2，阻止將花生四烯酸（arachidonic acid）轉換為前列腺素（prostaglandin），降低前列腺素介導的發炎訊號、痛覺敏感化與發燒反應。

​Reference(s):

1. Blanco FJ et al. (1999). Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 


2. Bugajski J et al. (2001). Involvement of constitutive (COX-1) and inducible cyclooxygenase (COX-2) in the adrenergic-induced ACTH and corticosterone secretion. J Physiol Pharmacol.

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