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The Sound of Evolution
Procaterol
丙卡特羅
Mechanism of action:
Procaterol 是一種支氣管擴張劑（bronchodilator），屬於選擇性 β₂-腎上腺素受體促效劑（selective β₂-adrenergic receptor agonist）。Procaterol 與支氣管平滑肌細胞膜上的 β₂ 受體結合後，啟動 Gs 蛋白，進而活化腺苷酸環化酶（adenylyl cyclase），使 cAMP 上升，活化蛋白激酶 A（protein kinase A），抑制肌球蛋白輕鏈激酶（myosin light chain kinase，MLCK），最終導致支氣管平滑肌放鬆。
Reference(s):
1. Kobayashi M et al. (2002). [beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers]. Nihon Kokyuki Gakkai Zasshi.
2. Yamasaki Y et al. (2004). [Beta 2-adrenoceptor polymorphism and effects of inhaled beta 2-stimulant (procaterol) and an anti-cholinergic drug (oxitropium) on the airway resistance]. Nihon Kokyuki Gakkai Zasshi.
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