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Progesterone

孕酮

Mechanism of action:

Progesterone 是一種類固醇荷爾蒙（steroid hormone），為脂溶性分子，可自由穿越細胞膜，在細胞質中結合於孕酮受體（progesterone receptor），包含 PR-A 與 PR-B，之後形成複合體，接著進入細胞核與 DNA 的孕酮反應元件（progesterone response element）結合，調控與生殖相關的基因表達。

​Reference(s):

1. Schumacher M et al. (2004). Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination. Growth Horm IGF Res. 


2. Hould FS et al. (1988). Progesterone receptors regulate gallbladder motility. J Surg Res. 


3. Payne VA et al. (1999). Homology modeling and substrate binding study of human CYP2C18 and CYP2C19 enzymes. Proteins.

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