The Sound of Evolution
Propofol
丙泊酚
Mechanism of action:
Propofol 是一種烷基酚類（alkylphenol）衍生物。Propofol 會結合於 GABA_A 受體上的 β 亞基跨膜區與 α 亞基形成的疏水性孔洞，增強 GABA 對該受體的作用，使氯離子通道開啟時間延長，導致神經元膜超極化（hyperpolarization），顯著抑制神經元放電。
Reference(s):
1. Vasile B et al. (2003). The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Med.
2. Ke JJ et al. (2008). A comparison of the effect of total intravenous anaesthesia with propofol and remifentanil and inhalational anaesthesia with isoflurane on the release of pro- and anti-inflammatory cytokines in patients undergoing open cholecystectomy. Anaesth Intensive Care.
3. Hong JY et al. (2008). Anaesthesia for day case excisional breast biopsy: propofol-remifentanil compared with sevoflurane-nitrous oxide. Eur J Anaesthesiol.