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The Sound of Evolution
Protamine sulfate
硫酸魚精蛋白
Mechanism of action:
Protamine sulfate 是一種拮抗抗凝血藥物的多胜肽（polypeptide antagonist of anticoagulants）。Protamine 為高度帶正電的鹼性多胜肽（富含 arginine），而肝素為高度帶負電的分子。 因此 protamine 是透過電荷與肝素結合，變成不具生物活性的 protamine-肝素的複合體，以抑制肝素的抗凝血作用。
Reference(s):
1. Sokolowska E et al. (2016). The toxicology of heparin reversal with protamine: past, present and future. Expert Opin Drug Metab Toxicol.
2. Bromfield SM et al. (2013). Heparin sensing and binding - taking supramolecular chemistry towards clinical applications. Chem Soc Rev.
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